Publications Research group Knolle

J Hepatol. 1995 Feb .

Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge.

Knolle P, Schlaak J, Uhrig A, Kempf P, Meyer zum Büschenfelde KH, Gerken G

Kupffer cells are involved in local immunoregulation in the liver by secretion of cytokines and direct cellular contact. They are able to influence the function of other liver cells, i.e. sinusoidal endothelial cells, Ito cells and hepatocytes. The three known major functions of Kupffer cells are clearance of endotoxin from the portal circulation, release of soluble mediators and presentation of antigen.

PMID: 7790711 [PubMed - in process]