CV  and Publications Percy A. Knolle

Percy A. Knolle, MD, *29.10.1962, married, two children

Current position

Proffesor of Mollecular Immunology, Technische Universität München

Direktor Institute of Molecular Immunology and Director Institut of Experimental Oncology, both at the University Hospital München rechts der Isar, Technische Universität München

Direktor Institute of Molecular Immunology and Experimental Immunology Faculty Weihenstephan, Technische Universität München

Cooption as Proffesor of Molecular Medicine, Medical Faculty, Friedrich-Wilchelm Universität Bonn

1982-1988      Study of Medicine at the Universities of Frankfurt, Paris, Birmingham,

                       Strasbourg, and Geneva

1984-1988      Stipend from the Studienstiftung des Deutschen Volkes

1989-1990      MD thesis at the German Cancer Reserch Center(Applied Immunology

                       Prof.Meuer) in Heidelberg

1990-1991      Postdoctoral fellow with the Bioreserch Corporation of BASF


1991-1997      Physician at the  1st.Medical Department (Prof. Meyerzum 

                       Büschenfelde), University of Mainz

1997               Qualification as Specialist in Internal Medicine and Hepatology

1997-2002      Independent research Group leader at the Centre for Molecular
                        Biology Heidelberg(ZMBH)

2001               Offers rejected for proffesorships at the Universities of Essen and


2002               Full Proffesor of Molecular Medicine and Immunology, University of


2002-2012      Founding Director Institutes of Molecular Medicine and
                       Experimental Immunology (IMMEI), University of Bonn

since 2013      Full Proffesor of Molecular Immunology and founding director Institute

                       of Molecular Immunology and Experimental Oncology at TUM



Academic positions and engagements


2003-2006  Co-Founder and Organizer of „Fachkolleg Immunologie“Studienstiftung des Deutschen Volkes

2004-2009              Head of the Faculty Committee for career support of young researchers (doubled the financial support from 2 to 4 M €/year because of implementation of successful career development programs for young researchers)

2004-2012                 Head of the Steering Committee of the Central Animal Facility University of Bonn advancing development of preclinical disease models for research

2004-2013             Head of the Core Facility Flow Cytometry and Cell Sorting, University of Bonn

2006-2012                  Co-Founder and Vice-speaker Sonderforschungsbereich 704

2007-2014                  Co-Founder and PI Sonderforschungsbereich 670

2009-2014                  Co-Founder and PI Sonderforschungsbereich TR57

2012-2014              Co-Founder and Member of the Executive Board of theExcellence Cluster ImmunoSensation at the University of Bonn


2010-2016                 Co-Founder Translational Research Initiative PeTRA developing nanoparticles for mucosal therapeutic vaccine delivery (together with Merck and Evonik)

2009-2015                Co-Founder Translational Research Initiative The Virtual Liver developing systems biology approaches for understanding liver (immune)biology

2012-17                     Co-Founder and Co-Leader Translational EU Research Initiative MIP-DILI developing predictive markers for detection and prevention of drug-induced liver injury (together with Astra Zeneca, Roche and others)




2001                          Research Award by the Volkswagenstiftung (1.5 Million €)



2001 to present          approximately 35 M € of grant support raised for research activities


Advisory Positions


2002-2006            S cientific Advisor for Global Life Sciences Venture Capital,

                              München – Zürich

Since 2006            Adhoc Scientific Advisor for Venture Capital Companies Germany

                              and Swizerland

Since 2011             Scientific Advisor for Johnson & Johnson Pharmaceuticals

Since 2012             Scientific Advisor for GILEAD

Since 2014             Scientific Advisor for MEDIMMUNE



2009                         PPAR- gamma agonists in the treament of CNS autoimmunity


2013                         Use of Prime-Jump Vaccination to overcome chronic infection

                                 and cancer

2014                         Hyper-IL-6 induced T cell vaccination





1.    Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan K H, Spicer J A, Demetris A J, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani J A, Knolle P, Wohlleber D, Kastenmuller W. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun 2018, 9: 4805.


2.    Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp L C, Knolle P A, Kolanus W, Diehl L. The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production. Sci Rep 2018, 8: 16123.


3.    Steiger K, Ballke S, Yen H Y, Seelbach O, Alkhamas A, Boxberg M, Schwamborn K, Knolle P A, Weichert W, Mogler C. [Histopathological research laboratories in translational research : Conception and integration into the infrastructure of pathological institutes]. Pathologe 2018.


4.    Shinde P V, Xu H C, Maney S K, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev V I, van Rooijen N, Scheu S, Pfeffer K, Crocker P R, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak T W, Brenner D, Pandyra A A, Hoell J I, Borkhardt A, Haussinger D, Lang K S, Lang P A. Tumor Necrosis Factor-Mediated Survival of CD169(+) Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J Virol 2018, 92.


5.    Manske K, Kallin N, Konig V, Schneider A, Kurz S, Bosch M, Welz M, Cheng R L, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle P A, Wohlleber D. Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes. Hepatology 2018, 68: 2089-2105.


6.    Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdorffer M, Koedel U, Hochst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T. Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity. Nat Immunol 2018, 19: 1341-1351.


7.    Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Mann L, Gunzer M, Wilhelm C, Kastenmuller W, Knolle P, Abdullah Z, Kurts C, Garbi N. Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation. J Allergy Clin Immunol 2018, 141: 416-419 e410.


8.    Alazawi W, Knolle P A. Interfering with Kupffer cell replenishment: New insights into liver injury. J Hepatol 2018.


9.    Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor T O, Stadler M, Meister M, Weber J, Ollinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Hochst B, Wohlleber D, Jors S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Huser N, Davis R J, Tschaharganeh D F, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell 2017, 31: 771-789 e776.


10. Wittlich M, Dudek M, Bottcher J P, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle P A, Wohlleber D. Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2. J Hepatol 2017, 66: 978-986.


11. Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R. TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation. Nat Commun 2017, 8: 15050.


12. Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Muller A J, Gruber A D, Knolle P, Guzman C A, Bruder D. Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver. Sci Rep 2017, 7: 43985.


13. Knopf A, Bahadori L, Fritsche K, Piontek G, Becker C C, Knolle P, Kruger A, Bier H, Li Y. Primary tumor-associated expression of CXCR4 predicts formation of local and systemic recurrency in head and neck squamous cell carcinoma. Oncotarget 2017, 8: 112739-112747.


14. Knolle P A. Hitting the right button: MAVS-mediated defense against HAV infection. Cell Res 2017, 27: 7-8.


15. Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra A A, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Hochst B, Knolle P A, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon P M, Scheu S, Bauer J, Chauhan J, Haussinger D, Willimsky G, Lohning M, Schadendorf D, Brandau S, Schuler M, Lang P A, Lang K S. Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression. Nat Commun 2017, 8: 14447.


16. Hochst B, Knolle P A. Checkpoint Inhibition in Head and Neck Cancer: Immune Therapeutic Options, Limitations, and Beyond. ORL J Otorhinolaryngol Relat Spec 2017, 79: 24-33.


17. Heuser C, Gotot J, Piotrowski E C, Philipp M S, Courreges C J F, Otte M S, Guo L, Schmid-Burgk J L, Hornung V, Heine A, Knolle P A, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C. Prolonged IKKbeta Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. Cell Rep 2017, 21: 578-586.


18. Herold M, Breuer J, Hucke S, Knolle P, Schwab N, Wiendl H, Klotz L. Liver X receptor activation promotes differentiation of regulatory T cells. PLoS One 2017, 12: e0184985.


19. Heine A, Flores C, Gevensleben H, Diehl L, Heikenwalder M, Ringelhan M, Janssen K P, Nitsche U, Garbi N, Brossart P, Knolle P A, Kurts C, Hochst B. Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination. Oncoimmunology 2017, 6: e1338995.


20. Hackstein C P, Assmus L M, Welz M, Klein S, Schwandt T, Schultze J, Forster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmuller W, Knolle P A*, Abdullah Z*. Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut 2017, 66: 507-518.


21. Beuke K, Schildberg F A, Pinna F, Albrecht U, Liebe R, Bissinger M, Schirmacher P, Dooley S, Bode J G, Knolle P A, Kummer U, Breuhahn K, Sahle S. Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction. FEBS J 2017, 284: 796-813.


22. Abdullah Z, Knolle P A. Liver macrophages in healthy and diseased liver. Pflugers Arch 2017, 469: 553-560.


23. Wohlleber D, Knolle P A. The role of liver sinusoidal cells in local hepatic immune surveillance. Clin Transl Immunology 2016, 5: e117.


24. Weiher H, Pircher H, Jansen-Durr P, Hegenbarth S, Knolle P, Grunau S, Vapola M, Hiltunen J K, Zwacka R M, Schmelzer E, Reumann K, Will H. A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells. BMC Res Notes 2016, 9: 128.


25. Siegmund S V, Wojtalla A, Schlosser M, Schildberg F A, Knolle P A, Nusing R M, Zimmer A, Strassburg C P, Singer M V. Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. Biochem Biophys Res Commun 2016, 470: 678-684.


26. Siegmund S V, Schlosser M, Schildberg F A, Seki E, De Minicis S, Uchinami H, Kuntzen C, Knolle P A, Strassburg C P, Schwabe R F. Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells. PLoS One 2016, 11: e0150893.


27. Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn A M, Quast T, Koch K, Nehring M, Konig J, Zweynert A, Harms F L, Steiner N, Limmer A, Forster I, Berberich-Siebelt F, Knolle P A, Wohlleber D, Kolanus W, Beyer M, Schultze J L, Burgdorf S. Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4. Proc Natl Acad Sci U S A 2016, 113: 10649-10654.


28. Rietscher R, Schroder M, Janke J, Czaplewska J, Gottschaldt M, Scherliess R, Hanefeld A, Schubert U S, Schneider M, Knolle P A, Lehr C M. Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity. Eur J Pharm Biopharm 2016, 102: 20-31.


29. Protzer U, Knolle P. "To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B. Gastroenterology 2016, 151: 805-806.


30. Ludwig-Portugall I, Bartok E, Dhana E, Evers B D, Primiano M J, Hall J P, Franklin B S, Knolle P A, Hornung V, Hartmann G, Boor P, Latz E, Kurts C. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. Kidney Int 2016, 90: 525-539.


31. Knolle P A, Wohlleber D. Immunological functions of liver sinusoidal endothelial cells. Cell Mol Immunol 2016, 13: 347-353.


32. Knolle P A. Staying local-antigen presentation in the liver. Curr Opin Immunol 2016, 40: 36-42.


33. Heine A, Schilling J, Grunwald B, Kruger A, Gevensleben H, Held S A, Garbi N, Kurts C, Brossart P, Knolle P, Diehl L, Hochst B. The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib. Cancer Immunol Immunother 2016, 65: 273-282.


34. Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordao M J, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle P A, Heikenwalder M, Schultze J L, Prinz M. Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J 2016, 35: 1730-1744.


35. Grunwald B, Vandooren J, Gerg M, Ahomaa K, Hunger A, Berchtold S, Akbareian S, Schaten S, Knolle P, Edwards D R, Opdenakker G, Kruger A. Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow. Mol Cancer Res 2016, 14: 1147-1158.


36. Grunwald B, Harant V, Schaten S, Fruhschutz M, Spallek R, Hochst B, Stutzer K, Berchtold S, Erkan M, Prokopchuk O, Martignoni M, Esposito I, Heikenwalder M, Gupta A, Siveke J, Saftig P, Knolle P, Wohlleber D, Kruger A. Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. Gastroenterology 2016, 151: 1011-1024 e1017.


37. Beyer M, Abdullah Z, Chemnitz J M, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde P V, Schmidleithner L, Kohne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang K S, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fatkenheuer G, Lang P A, Hartmann P, Knolle P A*, Schultze J L*. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol 2016, 17: 593-603.


38. Bauernfeind F, Niepmann S, Knolle P A, Hornung V. Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances. J Immunol 2016, 197: 2900-2908.


39. Zeisel M B, Lucifora J, Mason W S, Sureau C, Beck J, Levrero M, Kann M, Knolle P A, Benkirane M, Durantel D, Michel M L, Autran B, Cosset F L, Strick-Marchand H, Trepo C, Kao J H, Carrat F, Lacombe K, Schinazi R F, Barre-Sinoussi F, Delfraissy J F, Zoulim F. Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure. Gut 2015, 64: 1314-1326.


40. Witt A, Seeger J M, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jungst C, Schauss A C, Schull S, Wohlleber D, Knolle P A, Kronke M, Mauch C, Kashkar H. IAP antagonization promotes inflammatory destruction of vascular endothelium. EMBO Rep 2015, 16: 719-727.


41. Seubert B, Grunwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke J T, Lim N H, Nagase H, Simonavicius N, Heikenwalder M, Reinheckel T, Sleeman J P, Janssen K P, Knolle P A, Kruger A. Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology 2015, 61: 238-248.


42. Lang P A, Meryk A, Pandyra A A, Brenner D, Brustle A, Xu H C, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan G S, Duhan V, Homey B, Ohashi P S, Haussinger D, Knolle P A, Honke N, Mak T W, Lang K S. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ 2015, 22: 164-173.


43. Kobuch J, Cui H, Grunwald B, Saftig P, Knolle P A, Kruger A. TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice. Haematologica 2015, 100: 1005-1013.


44. Knolle P A, Bottcher J, Huang L R. The role of hepatic immune regulation in systemic immunity to viral infection. Med Microbiol Immunol 2015, 204: 21-27.


45. Hochst B, Mikulec J, Baccega T, Metzger C, Welz M, Peusquens J, Tacke F, Knolle P, Kurts C, Diehl L, Ludwig-Portugall I. Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis. PLoS One 2015, 10: e0119662.


46. Herold M, Posevitz V, Chudyka D, Hucke S, Gross C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H. B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway. J Immunol 2015, 195: 3584-3595.


47. Franken L, Klein M, Spasova M, Elsukova A, Wiedwald U, Welz M, Knolle P, Farle M, Limmer A, Kurts C. Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates. Sci Rep 2015, 5: 12940.


48. Boutaffala L, Bertrand M J, Remouchamps C, Seleznik G, Reisinger F, Janas M, Benezech C, Fernandes M T, Marchetti S, Mair F, Ganeff C, Hupalowska A, Ricci J E, Becher B, Piette J, Knolle P, Caamano J, Vandenabeele P, Heikenwalder M, Dejardin E. NIK promotes tissue destruction independently of the alternative NF-kappaB pathway through TNFR1/RIP1-induced apoptosis. Cell Death Differ 2015, 22: 2020-2033.


49. Bottcher J P, Beyer M, Meissner F, Abdullah Z, Sander J, Hochst B, Eickhoff S, Rieckmann J C, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch D H, Protzer U, Thimme R, Mann M, Kurts C, Schultze J L, Kastenmuller W, Knolle P A. Functional classification of memory CD8(+) T cells by CX3CR1 expression. Nat Commun 2015, 6: 8306.


50. Bottcher J, Knolle P A. Global transcriptional characterization of CD8+ T cell memory. Semin Immunol 2015, 27: 4-9.


51. Wolf M J, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschop M, Tumanov A V, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 2014, 26: 549-564.


52. Scholzel K, Schildberg F A, Welz M, Borner C, Geiger S, Kurts C, Heikenwalder M, Knolle P A, Wohlleber D. Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol 2014, 61: 600-608.


53. Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl J M, Maurice N J, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse M J, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Grone H J, Garbi N, Kastenmuller W, Knolle P A, Kurts C, Engel D R. Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. Cell 2014, 156: 456-468.


54. Nino-Castro A, Abdullah Z, Popov A, Thabet Y, Beyer M, Knolle P, Domann E, Chakraborty T, Schmidt S V, Schultze J L. The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes. Innate Immun 2014, 20: 401-411.


55. Knolle P A, Thimme R. Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology 2014, 146: 1193-1207.


56. Kaczmarek J, Homsi Y, van Uum J, Metzger C, Knolle P A, Kolanus W, Lang T, Diehl L. Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time. PLoS One 2014, 9: e99574.


57. Granzow M, Schierwagen R, Klein S, Kowallick B, Huss S, Linhart M, Mazar I G, Gortzen J, Vogt A, Schildberg F A, Gonzalez-Carmona M A, Wojtalla A, Kramer B, Nattermann J, Siegmund S V, Werner N, Furst D O, Laleman W, Knolle P, Shah V H, Sauerbruch T, Trebicka J. Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology 2014, 60: 334-348.


58. De Nardo D, Labzin L I, Kono H, Seki R, Schmidt S V, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg F A, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald M L, Hernandez N J, Williams B R, Knolle P, Kneilling M, Rocken M, Lutjohann D, Wright S D, Schultze J L, Latz E. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol 2014, 15: 152-160.


59. Bottcher J P, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C, Beyer M, Schultze J L, Kastenmuller W, Rose-John S, Knolle P A. IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function. Cell Rep 2014, 8: 1318-1327.


60. Abdullah Z, Knolle P A. Scaling of immune responses against intracellular bacterial infection. EMBO J 2014, 33: 2283-2294.


61. Willimsky G, Protzer U, Knolle P, Heikenwalder M. Adoptive T-cell therapy to treat liver cancer: is the liver microenvironment key? Oncotarget 2013, 4: 1117-1118.


62. Weber O, Mercer A A, Friebe A, Knolle P, Volk H D. Therapeutic immunomodulation using a virus--the potential of inactivated orf virus. Eur J Clin Microbiol Infect Dis 2013, 32: 451-460.


63. Schiedel A C, Lacher S K, Linnemann C, Knolle P A, Muller C E. Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms. Purinergic Signal 2013, 9: 351-365.


64. Riediger C, Wingender G, Knolle P, Aulmann S, Stremmel W, Encke J. Fms-like tyrosine kinase 3 receptor ligand (Flt3L)-based vaccination administered with an adenoviral vector prevents tumor growth of colorectal cancer in a BALB/c mouse model. J Cancer Res Clin Oncol 2013, 139: 2097-2110.


65. Paulsen D, Urban A, Knorr A, Hirth-Dietrich C, Siegling A, Volk H D, Mercer A A, Limmer A, Schumak B, Knolle P, Ruebsamen-Schaeff H, Weber O. Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models. PLoS One 2013, 8: e74605.


66. Nowatzky J, Knorr A, Hirth-Dietrich C, Siegling A, Volk H D, Limmer A, Knolle P, Weber O. Inactivated Orf virus (Parapoxvirus ovis) elicits antifibrotic activity in models of liver fibrosis. Hepatol Res 2013, 43: 535-546.


67. Krebs K, Bottinger N, Huang L R, Chmielewski M, Arzberger S, Gasteiger G, Jager C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology 2013, 145: 456-465.


68. Huang L R, Wohlleber D, Reisinger F, Jenne C N, Cheng R L, Abdullah Z, Schildberg F A, Odenthal M, Dienes H P, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle P A. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol 2013, 14: 574-583.


69. Hochst B, Schildberg F A, Sauerborn P, Gabel Y A, Gevensleben H, Goltz D, Heukamp L C, Turler A, Ballmaier M, Gieseke F, Muller I, Kalff J, Kurts C, Knolle P A, Diehl L. Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashionJ Hepatol 2013, 59: 528-535.


70. Hochheiser K, Heuser C, Krause T A, Teteris S, Ilias A, Weisheit C, Hoss F, Tittel A P, Knolle P A, Panzer U, Engel D R, Tharaux P L, Kurts C. Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression. J Clin Invest 2013, 123: 4242-4254.


71. Gottschalk C, Damuzzo V, Gotot J, Kroczek R A, Yagita H, Murphy K M, Knolle P A, Ludwig-Portugall I, Kurts C. Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. J Am Soc Nephrol 2013, 24: 543-549.


72. Bottcher J P, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Hochst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath M F, Busch D H, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze J L, Diehl L, Knolle P A. Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. Cell Rep 2013, 3: 779-795.


73. Wojtalla A, Herweck F, Granzow M, Klein S, Trebicka J, Huss S, Lerner R, Lutz B, Schildberg F A, Knolle P A, Sauerbruch T, Singer M V, Zimmer A, Siegmund S V. The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2012, 302: G873-887.


74. Wohlleber D, Kashkar H, Gartner K, Frings M K, Odenthal M, Hegenbarth S, Borner C, Arnold B, Hammerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes H P, Kurts C, Kronke M, Knolle P A. TNF-induced target cell killing by CTL activated through cross-presentation. Cell Rep 2012, 2: 478-487.


75. Stross L, Gunther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch D H, Knolle P, Sparwasser T, Protzer U. Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice. Hepatology 2012, 56: 873-883.


76. Schwandt T, Schumak B, Gielen G H, Jungerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff J C, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze J L, Burgdorf S, den Haan J M, Knolle P A, Limmer A. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J 2012, 31: 201-213.


77. Protzer U, Maini M K, Knolle P A. Living in the liver: hepatic infections. Nat Rev Immunol 2012, 12: 201-213.


78. Poppensieker K, Otte D M, Schurmann B, Limmer A, Dresing P, Drews E, Schumak B, Klotz L, Raasch J, Mildner A, Waisman A, Scheu S, Knolle P, Forster I, Prinz M, Maier W, Zimmer A, Alferink J. CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci U S A 2012, 109: 3897-3902.


79. Konermann A, Stabenow D, Knolle P A, Held S A, Deschner J, Jager A. Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation. Innate Immun 2012, 18: 745-752.


80. Konermann A, Gotz W, Wohlleber D, Knolle P, Deschner J, Jager A. Osteoimmunological mechanisms involved in orthodontically and bacterially induced periodontal stress. J Orofac Orthop 2012, 73: 430-439.


81. Knolle P A. The liver's imprint on CD8(+) T cell priming. J Hepatol 2012, 57: 718-719.


82. Hucke S, Flossdorf J, Grutzke B, Dunay I R, Frenzel K, Jungverdorben J, Linnartz B, Mack M, Peitz M, Brustle O, Kurts C, Klockgether T, Neumann H, Prinz M, Wiendl H, Knolle P, Klotz L. Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor gamma.

Brain 2012, 135: 1586-1605.


83. Huang L R, Gabel Y A, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle P A, Protzer U. Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology 2012, 142: 1447-1450 e1443.


84. Hosel M, Broxtermann M, Janicki H, Esser K, Arzberger S, Hartmann P, Gillen S, Kleeff J, Stabenow D, Odenthal M, Knolle P, Hallek M, Protzer U, Buning H. Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors. Hepatology 2012, 55: 287-297.


85. Hochst B, Schildberg F A, Bottcher J, Metzger C, Huss S, Turler A, Overhaus M, Knoblich A, Schneider B, Pantelis D, Kurts C, Kalff J C, Knolle P, Diehl L. Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice. Hepatology 2012, 56: 1924-1933.


86. Gotot J, Gottschalk C, Leopold S, Knolle P A, Yagita H, Kurts C, Ludwig-Portugall I. Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo. Proc Natl Acad Sci U S A 2012, 109: 10468-10473.


87. Brockschmidt A, Trost D, Peterziel H, Zimmermann K, Ehrler M, Grassmann H, Pfenning P N, Waha A, Wohlleber D, Brockschmidt F F, Jugold M, Hoischen A, Kalla C, Waha A, Seifert G, Knolle P A, Latz E, Hans V H, Wick W, Pfeifer A, Angel P, Weber R G. KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas. Brain 2012, 135: 1027-1041.


88. Beyer M, Schumak B, Weihrauch M R, Andres B, Giese T, Endl E, Knolle P A, Classen S, Limmer A, Schultze J L. In vivo expansion of naive CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration. PLoS One 2012, 7: e30422.


89. Bauernfeind F, Rieger A, Schildberg F A, Knolle P A, Schmid-Burgk J L, Hornung V. NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol 2012, 189: 4175-4181.


90. Abdullah Z, Schlee M, Roth S, Mraheil M A, Barchet W, Bottcher J, Hain T, Geiger S, Hayakawa Y, Fritz J H, Civril F, Hopfner K P, Kurts C, Ruland J, Hartmann G, Chakraborty T, Knolle P A. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J 2012, 31: 4153-4164.


91. Abdullah Z, Geiger S, Nino-Castro A, Bottcher J P, Muraliv E, Gaidt M, Schildberg F A, Riethausen K, Flossdorf J, Krebs W, Chakraborty T, Kurts C, Schultze J L, Knolle P A, Klotz L. Lack of PPARgamma in myeloid cells confers resistance to Listeria monocytogenes infection. PLoS One 2012, 7: e37349.


92. Tittel A P, Heuser C, Ohliger C, Knolle P A, Engel D R, Kurts C. Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol 2011, 22: 1435-1441.


93. Schildberg F A, Wojtalla A, Siegmund S V, Endl E, Diehl L, Abdullah Z, Kurts C, Knolle P A. Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology 2011, 54: 262-272.


94. Schildberg F A, Kurts C, Knolle P A. Prominent regulatory but weak antigen-presenting cell function of hepatic stellate cells. Hepatology 2011, 54: 1108.


95. Roderburg C, Urban G W, Bettermann K, Vucur M, Zimmermann H, Schmidt S, Janssen J, Koppe C, Knolle P, Castoldi M, Tacke F, Trautwein C, Luedde T. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis.Hepatology 2011, 53: 209-218.


96. Klotz L, Knolle P. Nuclear receptors: TH17 cell control from within. FEBS Lett 2011, 585: 3764-3769.


97. Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer H P, Schorle H. Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia. PLoS One 2011, 6: e22034.


98. Hochheiser K, Engel D R, Hammerich L, Heymann F, Knolle P A, Panzer U, Kurts C. Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria. J Am Soc Nephrol 2011, 22: 306-316.


99. Fiebig H H, Siegling A, Volk H D, Friebe A, Knolle P, Limmer A, Weber O. Inactivated orf virus (Parapoxvirus ovis) induces antitumoral activity in transplantable tumor models. Anticancer Res 2011, 31: 4185-4190.


100. Bottcher J P, Knolle P A, Stabenow D. Mechanisms balancing tolerance and immunity in the liver. Dig Dis 2011, 29: 384-390.


101. Beyer M, Thabet Y, Muller R U, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout S L, Krebs W, Schonfeld E A, Bottcher J, Golovina T, Mayer C T, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen K L, Blazar B R, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle P A, Wickenhauser C, Kolanus W, Schermer B, Bluestone J A, Barry S C, Sparwasser T, Riley J L, Schultze J L. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 2011, 12: 898-907.


102. Beyer M, Classen S, Endl E, Kochanek M, Weihrauch M R, Debey-Pascher S, Knolle P A, Schultze J L. Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3. Clin Dev Immunol 2011, 2011: 734036.


103. Thomson A W, Knolle P A. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol 2010, 10: 753-766.


104. Stabenow D, Frings M, Truck C, Gartner K, Forster I, Kurts C, Tuting T, Odenthal M, Dienes H P, Cederbrant K, Protzer U, Knolle P A. Bioluminescence imaging allows measuring CD8 T cell function in the liver. Hepatology 2010, 51: 1430-1437.


105. Semmling V, Lukacs-Kornek V, Thaiss C A, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey D I, Savage P B, Knolle P A, Kolanus W, Forster I, Kurts C. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 2010, 11: 313-320.


106. Schurich A, Berg M, Stabenow D, Bottcher J, Kern M, Schild H J, Kurts C, Schuette V, Burgdorf S, Diehl L, Limmer A, Knolle P A. Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells. J Immunol 2010, 184: 4107-4114.


107. Mayer G, Ahmed M S, Dolf A, Endl E, Knolle P A, Famulok M. Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures. Nat Protoc 2010, 5: 1993-2004.


108. Kurts C, Robinson B W, Knolle P A. Cross-priming in health and disease. Nat Rev Immunol 2010, 10: 403-414.


109. Konig K, Diehl L, Rommerscheidt-Fuss U, Golletz C, Quast T, Kahl P, Kolanus W, Knolle P, Buettner R, Heukamp L C. Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration. J Immunol 2010, 185: 1466-1475.


110. Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase M J, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle P A. Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 2010, 138: 336-346.


111. Kern M, Popov A, Kurts C, Schultze J L, Knolle P A. Taking off the brakes: T cell immunity in the liver. Trends Immunol 2010, 31: 311-317.


112. Engel D R, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle P A, Kalff J C, Kurts C. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med 2010, 16: 1407-1413.


113. Burgdorf S, Schuette V, Semmling V, Hochheiser K, Lukacs-Kornek V, Knolle P A, Kurts C. Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proc Natl Acad Sci U S A 2010, 107: E48-49; author reply E50-41.


114. von Oppen N, Schurich A, Hegenbarth S, Stabenow D, Tolba R, Weiskirchen R, Geerts A, Kolanus W, Knolle P, Diehl L. Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization. Hepatology 2009, 49: 1664-1672.


115. Smedsrod B, Le Couteur D, Ikejima K, Jaeschke H, Kawada N, Naito M, Knolle P, Nagy L, Senoo H, Vidal-Vanaclocha F, Yamaguchi N. Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium. Liver Int 2009, 29: 490-501.


116. Schurich A, Bottcher J P, Burgdorf S, Penzler P, Hegenbarth S, Kern M, Dolf A, Endl E, Schultze J, Wiertz E, Stabenow D, Kurts C, Knolle P. Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells. Hepatology 2009, 50: 909-919.


117. Ney J T, Schmidt T, Kurts C, Zhou Q, Eckert D, Felsher D W, Schorle H, Knolle P, Tuting T, Barchet W, Buttner R, Limmer A, Gutgemann I. Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Hepatology 2009, 49: 471-481.


118. Linnemann C, Schildberg F A, Schurich A, Diehl L, Hegenbarth S I, Endl E, Lacher S, Muller C E, Frey J, Simeoni L, Schraven B, Stabenow D, Knolle P A. Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling. Immunology 2009, 128: e728-737.


119. Klotz L, Hucke S, Thimm D, Classen S, Gaarz A, Schultze J, Edenhofer F, Kurts C, Klockgether T, Limmer A, Knolle P, Burgdorf S. Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1. J Immunol 2009, 183: 129-136.


120. Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle P A. The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med 2009, 206: 2079-2089.


121. Schrage A, Loddenkemper C, Erben U, Lauer U, Hausdorf G, Jungblut P R, Johnson J, Knolle P A, Zeitz M, Hamann A, Klugewitz K. Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1. Histochem Cell Biol 2008, 129: 441-451.


122. Schildberg F A, Hegenbarth S I, Schumak B, Scholz K, Limmer A, Knolle P A. Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells. Eur J Immunol 2008, 38: 957-967.


123. Raddatz M S, Dolf A, Endl E, Knolle P, Famulok M, Mayer G. Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting. Angew Chem Int Ed Engl 2008, 47: 5190-5193.


124. Ortler S, Leder C, Mittelbronn M, Zozulya A L, Knolle P A, Chen L, Kroner A, Wiendl H. B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. Eur J Immunol 2008, 38: 1734-1744.


125. Diehl L, Schurich A, Grochtmann R, Hegenbarth S, Chen L, Knolle P A. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology 2008, 47: 296-305.


126. Busch A, Quast T, Keller S, Kolanus W, Knolle P, Altevogt P, Limmer A. Transfer of T cell surface molecules to dendritic cells upon CD4+ T cell priming involves two distinct mechanisms. J Immunol 2008, 181: 3965-3973.


127. Klotz L, Diehl L, Dani I, Neumann H, von Oppen N, Dolf A, Endl E, Klockgether T, Engelhardt B, Knolle P. Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro. J Neuroimmunol 2007, 190: 34-43.


128. Klotz L, Dani I, Edenhofer F, Nolden L, Evert B, Paul B, Kolanus W, Klockgether T, Knolle P, Diehl L. Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy. J Immunol 2007, 178: 2122-2131.


129. Fievez L, Desmet C, Henry E, Pajak B, Hegenbarth S, Garze V, Bex F, Jaspar F, Boutet P, Gillet L, Vanderplasschen A, Knolle P A, Leo O, Moser M, Lekeux P, Bureau F. STAT5 is an ambivalent regulator of neutrophil homeostasis. PLoS One 2007, 2: e727.


130. Burgdorf S, Kautz A, Bohnert V, Knolle P A, Kurts C. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 2007, 316: 612-616.


131. Wingender G, Schumak B, Schurich A, Gessner J E, Endl E, Limmer A, Knolle P A. Rapid and preferential distribution of blood-borne alphaCD3epsilonAb to the liver is followed by local stimulation of T cells and natural killer T cells. Immunology 2006, 117: 117-126.


132. Wingender G, Garbi N, Schumak B, Jungerkes F, Endl E, von Bubnoff D, Steitz J, Striegler J, Moldenhauer G, Tuting T, Heit A, Huster K M, Takikawa O, Akira S, Busch D H, Wagner H, Hammerling G J, Knolle P A, Limmer A. Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur J Immunol 2006, 36: 12-20.


133. Wingender G, Berg M, Jungerkes F, Diehl L, Sullivan B A, Kronenberg M, Limmer A, Knolle P A. Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells. Eur J Immunol 2006, 36: 570-582.


134. Schmitz V, Dombrowski F, Prieto J, Qian C, Diehl L, Knolle P, Sauerbruch T, Caselmann W H, Spengler U, Leifeld L. Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure. Hepatology 2006, 44: 430-439.


135. Ryschich E, Lizdenis P, Ittrich C, Benner A, Stahl S, Hamann A, Schmidt J, Knolle P, Arnold B, Hammerling G J, Ganss R. Molecular fingerprinting and autocrine growth regulation of endothelial cells in a murine model of hepatocellular carcinoma. Cancer Res 2006, 66: 198-211.


136. Knolle P A. Involvement of the liver in the induction of CD8 T cell tolerance towards oral antigen. Z Gastroenterol 2006, 44: 51-56.


137. Knolle P A. Cognate interaction between endothelial cells and T cells. Results Probl Cell Differ 2006, 43: 151-173.


138. Beyer M, Kochanek M, Giese T, Endl E, Weihrauch M R, Knolle P A, Classen S, Schultze J L. In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma. Blood 2006, 107: 3940-3949.


139. Berg M, Wingender G, Djandji D, Hegenbarth S, Momburg F, Hammerling G, Limmer A, Knolle P. Cross-presentation of antigens from apoptotic tumor cells by liver sinusoidal endothelial cells leads to tumor-specific CD8+ T cell tolerance. Eur J Immunol 2006, 36: 2960-2970.


140. Viebig N K, Wulbrand U, Forster R, Andrews K T, Lanzer M, Knolle P A. Direct activation of human endothelial cells by Plasmodium falciparum-infected erythrocytes. Infect Immun 2005, 73: 3271-3277.


141. Viebig N K, Andrews K T, Kooyk Y, Lanzer M, Knolle P A. Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes. Parasitol Res 2005, 96: 247-252.


142. Uhrig A, Banafsche R, Kremer M, Hegenbarth S, Hamann A, Neurath M, Gerken G, Limmer A, Knolle P A. Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver.

J Leukoc Biol 2005, 77: 626-633.


143. Limmer A, Ohl J, Wingender G, Berg M, Jungerkes F, Schumak B, Djandji D, Scholz K, Klevenz A, Hegenbarth S, Momburg F, Hammerling G J, Arnold B, Knolle P A. Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur J Immunol 2005, 35: 2970-2981.


144. Klotz L, Schmidt M, Giese T, Sastre M, Knolle P, Klockgether T, Heneka M T. Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients. J Immunol 2005, 175: 4948-4955.


145. Charbel Issa P, Scholl H P, Holz F G, Knolle P, Kurts C. [The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)]. Ophthalmologe 2005, 102: 1036-1042.


146. Beyer M, Kochanek M, Darabi K, Popov A, Jensen M, Endl E, Knolle P A, Thomas R K, von Bergwelt-Baildon M, Debey S, Hallek M, Schultze J L. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005, 106: 2018-2025.


147. Weber O, Siegling A, Friebe A, Limmer A, Schlapp T, Knolle P, Mercer A, Schaller H, Volk H D. Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus. J Gen Virol 2003, 84: 1843-1852.


148. Knolle P A, Limmer A. Control of immune responses by savenger liver endothelial cells. Swiss Med Wkly 2003, 133: 501-506.


149. Andrews K T, Viebig N K, Wissing F, Klatt N, Oster N, Wickert H, Knolle P, Lanzer M. A human schwannoma cell line supports the in vitro adhesion of Plasmodium falciparum infected erythrocytes to chondroitin-4-sulfate. Parasitol Res 2003, 89: 188-193.


150. Sacher T, Knolle P, Nichterlein T, Arnold B, Hammerling G J, Limmer A. CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes. Eur J Immunol 2002, 32: 3628-3637.


151. Klugewitz K, Blumenthal-Barby F, Schrage A, Knolle P A, Hamann A, Crispe I N. Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization. J Immunol 2002, 169: 2407-2413.


152. Seebach J D, Schneider M K, Comrack C A, LeGuern A, Kolb S A, Knolle P A, Germana S, DerSimonian H, LeGuern C, Sachs D H. Immortalized bone-marrow derived pig endothelial cells. Xenotransplantation 2001, 8: 48-61.


153. Limmer A, Knolle P A. Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. Arch Immunol Ther Exp (Warsz) 2001, 49 Suppl 1: S7-11.


154. Knolle P A, Limmer A. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol 2001, 22: 432-437.


155. Breiner K M, Schaller H, Knolle P A. Endothelial cell-mediated uptake of a hepatitis B virus: a new concept of liver targeting of hepatotropic microorganisms. Hepatology 2001, 34: 803-808.


156. Bashirova A A, Geijtenbeek T B, van Duijnhoven G C, van Vliet S J, Eilering J B, Martin M P, Wu L, Martin T D, Viebig N, Knolle P A, KewalRamani V N, van Kooyk Y, Carrington M. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J Exp Med 2001, 193: 671-678.


157. Banafsche R, Gunther L, Nefflen J U, Moutsiou S, Knolle P A, Herfarth C, Klar E. NF-kappa B antisense oligonucleotides reduce leukocyte-endothelial interaction in hepatic ischemia-reperfusion. Transplant Proc 2001, 33: 3726-3727.


158. Limmer A, Ohl J, Kurts C, Ljunggren H G, Reiss Y, Groettrup M, Momburg F, Arnold B, Knolle P A. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance.Nat Med 2000, 6: 1348-1354.


159. Knolle P A, Gerken G. Local control of the immune response in the liver. Immunol Rev 2000, 174: 21-34.


160. Hegenbarth S, Gerolami R, Protzer U, Tran P L, Brechot C, Gerken G, Knolle P A. Liver sinusoidal endothelial cells are not permissive for adenovirus type 5. Hum Gene Ther 2000, 11: 481-486.


161. Knolle P A, Schmitt E, Jin S, Germann T, Duchmann R, Hegenbarth S, Gerken G, Lohse A W. Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 1999, 116: 1428-1440.


162. Knolle P A, Germann T, Treichel U, Uhrig A, Schmitt E, Hegenbarth S, Lohse A W, Gerken G. Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells. J Immunol 1999, 162: 1401-1407.


163. Duchmann R, May E, Heike M, Knolle P, Neurath M, Meyer zum Buschenfelde K H. T cell specificity and cross reactivity towards enterobacteria, bacteroides, bifidobacterium, and antigens from resident intestinal flora in humans. Gut 1999, 44: 812-818.


164. Knolle P A, Uhrig A, Protzer U, Trippler M, Duchmann R, Meyer zum Buschenfelde K H, Gerken G. Interleukin-10 expression is autoregulated at the transcriptional level in human and murine Kupffer cells. Hepatology 1998, 27: 93-99.


165. Knolle P A, Uhrig A, Hegenbarth S, Loser E, Schmitt E, Gerken G, Lohse A W. IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules. Clin Exp Immunol 1998, 114: 427-433.


166. Knolle P A, Kremp S, Hohler T, Krummenauer F, Schirmacher P, Gerken G. Viral and host factors in the prediction of response to interferon-alpha therapy in chronic hepatitis C after long-term follow-up. J Viral Hepat 1998, 5: 399-406.


167. Knolle P A, Loser E, Protzer U, Duchmann R, Schmitt E, zum Buschenfelde K H, Rose-John S, Gerken G. Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10. Clin Exp Immunol 1997, 107: 555-561.


168. Knolle P A, Eckardt A J, Protzer-Knolle U, Schirmacher P, Dienes H P, Meyer zum Buschenfelde K H, Gerken G. Circulating ICAM-1 (sCD54) and LFA-3 (sCD58) in chronic hepatitis B--a longitudinal study in patients treated with interferon-alpha. Z Gastroenterol 1997, 35: 459-467.


169. Hohler T, Gerken G, Notghi A, Knolle P, Lubjuhn R, Taheri H, Schneider P M, Meyer zum Buschenfelde K H, Rittner C. MHC class II genes influence the susceptibility to chronic active hepatitis C. J Hepatol 1997, 27: 259-264.


170. Gerken G, Knolle P, Jakobs S, Meyer zum Buschenfelde K H. Quantification and genotyping of serum HCV-RNA in patients with chronic hepatitis C undergoing interferon treatment. Arch Virol 1997, 142: 459-464.


171. Duchmann R, Scherer H, Neurath M, Knolle P, Meyer zum Buschenfelde K H. Normal interleukin-12 production in individuals with antibodies to Helicobacter pylori. APMIS 1997, 105: 824-830.


172. Wittig B M, Kaulen H, Thees R, Schmitt C, Knolle P, Stock J, Meyer zum Buschenfelde K H, Dippold W. Elevated serum E-selectin in patients with liver metastases of colorectal cancer. Eur J Cancer 1996, 32A: 1215-1218.


173. Trippler M, Hampl H, Goergen B, Spies U, Knolle P, Grimm B, Meyer zum Buschenfelde K H, Gerken G. Ligase chain reaction (LCR) assay for semi-quantitative detection of HBV DNA in mononuclear leukocytes of patients with chronic hepatitis B. J Viral Hepat 1996, 3: 267-272.


174. Protzer-Knolle U, Knolle P, Schiedhelm E, Meyer zum Buschenfelde K H, Gerken G. Semiquantitative assessment of pre-core stop-codon mutant and wildtype hepatitis B virus during the course of chronic hepatitis B using a new PCR-based assay. Arch Virol 1996, 141: 2091-2101.


175. Protzer U, Trippler M, Ohl J, Knolle P, Duchmann R, Meyer zum Buschenfelde K H, Gerken G. Rare pre-core stop-codon mutant nt. 1897 predominates over wide-spread mutant nt. 1896 in an unusual course of chronic hepatitis B. J Viral Hepat 1996, 3: 155-162.


176. Lohse A W, Knolle P A, Bilo K, Uhrig A, Waldmann C, Ibe M, Schmitt E, Gerken G, Meyer Zum Buschenfelde K H. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology 1996, 110: 1175-1181.


177. Knolle P A, Gerken G, Loser E, Dienes H P, Gantner F, Tiegs G, Meyer zum Buschenfelde K H, Lohse A W. Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice. Hepatology 1996, 24: 824-829.


178. Ibe M, Knolle P, Beck T, Meyer zum Buschenfelde K H, Gerken G. [HIV and pregnancy: risks of transmission and therapeutic possibilities]. Gynakol Geburtshilfliche Rundsch 1996, 36: 188-193.


179. Duchmann R, Schmitt E, Knolle P, Meyer zum Buschenfelde K H, Neurath M. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 1996, 26: 934-938.


180. Schlaak J F, Schwarting A, Knolle P, Meyer zum Buschenfelde K H, Mayet W. Effects of Th1 and Th2 cytokines on cytokine production and ICAM-1 expression on synovial fibroblasts. Ann Rheum Dis 1995, 54: 560-565.


181. Knolle P, Schlaak J, Uhrig A, Kempf P, Meyer zum Buschenfelde K H, Gerken G. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol 1995, 22: 226-229.


182. Knolle P, Lohr H, Treichel U, Dienes H P, Lohse A, Schlaack J, Gerken G. Parenchymal and nonparenchymal liver cells and their interaction in the local immune response. Z Gastroenterol 1995, 33: 613-620.


183. Wolfel T, Schirmacher P, Schlaak J, Knolle P, Dienes H P, Dippold W, Meyer zum Buschenfelde K H, Gerken G. Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection. Clin Investig 1994, 72: 1030-1036.


184. Knolle P, Mayet W, Lohse A W, Treichel U, Meyer zum Buschenfelde K H, Gerken G. Complete congenital heart block in autoimmune hepatitis (SLA-positive). J Hepatol 1994, 21: 224-226.


185. Neurath M, Benzing A, Knolle P, Grundmann H, Dippold W, Meyer zum Buschenfelde K H. [Acute respiratory failure in tropical malaria during pregnancy. Successful treatment using extracorporeal CO2 elimination].Dtsch Med Wochenschr 1993, 118: 1060-1066.


186. Hoffmann J C, Dengler T J, Knolle P A, Albert-Wolf M, Roux M, Wallich R, Meuer S C. A soluble form of the adhesion receptor CD58 (LFA-3) is present in human body fluids. Eur J Immunol 1993, 23: 3003-3010.


187. Goke M, Neurath M, Braunstein S, Daniello S, Knolle P, Dippold W, Meyer zum Buschenfelde K H. Brucellosis: differential diagnosis of acute abdominal pain. Z Gastroenterol 1993, 31: 671-674.


188. Dengler T J, Hoffmann J C, Knolle P, Albert-Wolf M, Roux M, Wallich R, Meuer S C. Structural and functional epitopes of the human adhesion receptor CD58 (LFA-3). Eur J Immunol 1992, 22: 2809-2817.