J Gene Med. 2004 Aug .

Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer.

Huth S, Lausier J, Gersting SW, Rudolph C, Plank C, Welsch U, Rosenecker J

Gene delivery by the use of magnetic forces, so-called magnetofection, has been shown to enhance transfection efficiency of viral and non-viral systems up to several-hundred-fold. For this purpose gene carriers, such as polyethylenimine (PEI), are associated with superparamagnetic nanoparticles and complexed with plasmid DNA. Gene delivery is targeted by the application of a magnetic field.

PMID: 15293351 [PubMed - in process]