Osteoarthritis Cartilage. 2004 Sep .

Inducible nonviral gene expression in the treatment of osteochondral defects.

Ueblacker P, Wagner B, Krüger A, Vogt S, DeSantis G, Kennerknecht E, Brill T, Hillemanns M, Salzmann GM, Imhoff AB, Plank C, Gänsbacher B, Martinek V

The repair of osteochondral defects with chondrocytes genetically modified to express desired growth factors promises great potential in orthopaedic therapy. Controlled expression of the transgenes is required in many instances. The objective of the present study was to demonstrate the inducibility of tetracycline-responsive transgene expression in osteochondral defects in the knee joint filled with genetically modified chondrocyte implants.

PMID: 15325637 [PubMed - in process]