Tumors employ various mechanisms to escape elimination by the immune system. In addition to the local induction of immunosuppressive cell types such as regulatory T cells or myeloid derived suppressor cells, tumor antigen shedding into the circulation may suppress antitumor CD8(+) T-cell function via tolerogenic liver sinusoidal endothelial cells.

PMID: 23264914 [PubMed - in process]