J Nucl Med. 2004 Oct .

Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation.

Anton M, Wittermann C, Haubner R, Simoes M, Reder S, Essien B, Wagner B, Henke J, Erhardt W, Noll S, Hackett NR, Crystal RG, Schwaiger M, Gansbacher B, Bengel FM

Coexpression of a reporter gene and a therapeutic gene may allow for noninvasive monitoring of cardiac gene therapy. We sought to evaluate the usefulness of an adenoviral vector expressing mutant herpesviral thymidine kinase reporter gene (HSV1-sr39tk) and vascular endothelial growth factor (VEGF) 121 in independent expression cassettes (Ad4tk).

PMID: 15471843 [PubMed - in process]