J Hepatol. 2016 Dec 23.

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle PA, Wohlleber D

Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to formation of memory T cells that is preceded by transient GzmB expression. Here we provide evidence for a so far unrecognized CD4 T helper cell-function in LSEC-induced CD8 T cell-activation.

PMID: 28025060 [PubMed - as supplied by publisher]